Jennifer Amadeo-Holl works in the Artist Building, located in the historic Fort Point district of Boston. She has exhibited nationally and internationally, including in Sweden, Finland and Chile and a touring exhibit of South America and Asia. She has received a NEFA award, a NEFA -Benton award, a Trustman Fellowship, the Harvard-McCord Arts Prize, and a two-year Swedish Institute Fellowship. Her work is represented in public and private collections, including AFA Konstförening, Biogen, Fidelity, Excel, Harvard Management, The London School of Economics, Oxfam, Svenska Institut, Swedish Television, and Tokio Millenium.

Critics have called Amadeo-Holl's work "knockout, confident painting" exhibiting "a marvelous synthesis of visual energy", with imagery that "rises and falls out of mists of paint that disrupt our expectation of space and read like dreams", and works that "tease, drawing you into detail that resonates, then pushing you away with their unsettling context".